IN IN552DEN2015A
[0001] The present disclosure provides antibodies specific for an epitope present on CD22. The antibodies are useful in various treatment diagnostic and monitoring applications which are also provided. An anti CD22 antibody of the present disclosure can in some cases induce apoptosis in a cell that expresses CD22 on its cell surface. A subject antibody specifically binds a CD22 polypeptide where the epitope comprises amino acid residues within a CD22 antigen (e.g. within amino acids 1 to 847 within amino acids 1 759 within amino acids 1 751 or within amino acids 1 670 of a CD22 amino acid sequence).
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