IN IN11156DELNP2014A
The invention relates to of analyzing vector supernatants useful for transducing T cells destined for administration to a human subject. The invention also related to methods of analyzing transduced T cells destined for administration to a human subject. The invention provides a method of analyzing a genetically modified T cell to detect a contaminant wherein the genetically modified T cell comprises a nucleic acid encoding a chimeric antigen receptor (CAR) wherein the CAR comprises an antigen binding domain a transmembrane domain a costimulatory signaling region and a signaling domain. In one embodiment the contaminant is at least one selected from the group consisting of endotoxin mycoplasma replication competent lentivirus (RCL) p24 VSV G nucleic acid HN gag residual anti CD3/anti CD28 coated beads mouse antibodies pooled human serum bovine serum albumin bovine serum culture media components vector packaging cell or plasmid components a bacterium and a fungus.
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