CN CN122464974A
本发明涉及储粮害虫防治领域，公开了一种TcOBP26基因在调控储粮害虫变态发育中的应用，利用靶向TcOBP26基因的RNAi技术敲低TcOBP26基因的表达，或者将TcOBP26基因编码的蛋白作为筛选靶点阻断20‑羟基蜕皮酮的结合，从而阻断储粮害虫的变态发育。通过显微注射向赤拟谷盗等储粮害虫递送靶向TcOBP26基因的双链RNA溶液，导致害虫化蛹与羽化失败，产生不可逆的发育障碍。本发明还公开了将TcOBP26蛋白进行同源建模作为受体靶点，通过分子对接计算潜在位点的结合亲和力来筛选特异性防控药剂的方法。本发明提供了基于激素转运蛋白靶向干预的防治途径，能够有效规避传统化学杀虫剂的抗药性问题。
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